منابع مشابه
A Bayesian Method for Evaluating and Discovering Disease Loci Associations
BACKGROUND A genome-wide association study (GWAS) typically involves examining representative SNPs in individuals from some population. A GWAS data set can concern a million SNPs and may soon concern billions. Researchers investigate the association of each SNP individually with a disease, and it is becoming increasingly commonplace to also analyze multi-SNP associations. Techniques for handlin...
متن کاملCellular Metabolic Network Analysis: Discovering Important Reactions in Treponema pallidum
T. pallidum, the syphilis-causing pathogen, performs very differently in metabolism compared with other bacterial pathogens. The desire for safe and effective vaccine of syphilis requests identification of important steps in T. pallidum's metabolism. Here, we apply Flux Balance Analysis to represent the reactions quantitatively. Thus, it is possible to cluster all reactions in T. pallidum. By c...
متن کاملPathWave: discovering patterns of differentially regulated enzymes in metabolic pathways
MOTIVATION Gene expression profiling by microarrays or transcript sequencing enables observing the pathogenic function of tumors on a mesoscopic level. RESULTS We investigated neuroblastoma tumors that clinically exhibit a very heterogeneous course ranging from rapid growth with fatal outcome to spontaneous regression and detected regulatory oncogenetic shifts in their metabolic networks. In ...
متن کاملConstrained metabolic network analysis: discovering pathways using CP(Graph)
Biochemical networks – networks composed of the building blocks of the cell and their interactions are qualitative descriptions of the working of the cell. Such networks can be modeled as graphs. Metabolic networks are typical examples of such networks. They are composed of biochemical entities participating to reactions as substrates or products. Such a network can be modeled as a bipartite di...
متن کاملMolecular epidemiology of hormone-metabolic loci in prostate cancer.
In the United States, some 180,400 men were diagnosed with prostate cancer in 2000 alone, and 31,900 men died of the disease during that same year (1). In fact, prostate cancer is the most commonly diagnosed malignancy among men in the United States (1). Prostate cancer is rare before the age of 30 years, but the rate of increase thereafter is such that by the time a man is 90 years old, he has...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Biology
سال: 2003
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20030123-01